A　novel　integrated　CMOS　smart　detector　which　is　intended　to　provide　flexible　low　noise　amplification　and　multiplexing　component　is　presented　in　this　paper.　Low　level　current　output　devices,　such　as　a　photodiode　array,　can　be　directly　connected　to　its　input.　It　has　64　channels,　and　each　channel　has　a　photo-sensitive　preamplifier　and　the　ability　to　provide　correlated　double　sampling　(CDS)　and　holding.　This　chip　may　also　be　used　as　general-purposed　multi-input　multiplexer　for　medical,　scientific,　or　industrial　instrument　applications.　There　are　no　similar　products　reported　in　China　yet.　The　test　results　show　that　the　expected　functions　of　the　chip　can　be　fulfilled.　©2010　IEEE.