Innovation　resource　utilization　is　closely　related　with　the　capability　of　transforming　regional　innovation　resource　into　innovation　income.　While　the　issue　of　industry　cluster　innovation　network　and　its　performance　becomes　a　hot　topic　in　recent　research,　we　posit　that　innovation　network　structure　could　influence　the　capability　of　network＇s　innovation　resource　utilization　and　thus　enhance　performance.　First　of　all,　we　advance　simulation　research　framework　based　on　complex　adaptive　system　theory.　Then　we　put　forward　the　research　hypothesis　and　establish　the　adaptive　model　of　innovation　network　structure　influences　innovation　resource　utilization　based　on　above　simulation　research　framework.　Finally　the　simulation　study　of　innovation　network　structure　influences　innovation　resource　utilization　has　been　done　on　Repast　simulation　platform,　and　empirical　study　also　be　used　for　verification.　The　results　show　that　the　changes　of　the　network　structure　could　cause　the　agents　in　innovation　network　choosing　different　utilization　mechanism　and　by　this　way　to　influence　innovation　resource　utilization.　©2010　IEEE.