Electrocatalytic　hydrodechlorination　is　deemed　as　a　promising　environmental　remediation　technology　for　fast　and　effective　detoxification　of　halogenated　antibiotic　pollutants.　In　this　study,　a　novel　nickel　(Ni)　foam　electrode　decorated　by　ultrafine　palladium　(Pd)　nanoparticles　(denoted　as　Pd@Ni-foam)　was　reported　for　electrocatalytic　dechlorination　of　florfenicol　(FLO,　a　typical　antibiotic).　The　Pd@Ni-foam　electrode　was　synthesized　via　a　facile　and　simple　spontaneous　galvanic　replacement　of　surface　Ni　atoms　of　Ni　foam　with　Pd　precursor.　The　obtained　Pd@Ni-foam　catalyst　showed　an　excellent　performance　on　electrochemical　dechloridation　of　FLO.　The　dechloridation　efficiency　of　FLO　(20　mg　L-1)　reached　99.5%　with　the　dechloridation　rate　as　fast　as　16.58　mg　min(-1)　at　cathode　potential　of　-1.2　V　(vs.　saturated　Ag/AgCl),　which　far　prevailed　over　pure　Ni　foam　(2.63　mg　min(-1))　and　commercial　Pd/C　(11.32　mg　min(-1)).　The　reaction　rate　constant　(0.044　min(-1))　of　FLO　dechloridation　at　Pd@Ni-foam　electrode　was　44　and　4.4　times　higher　than　that　of　pure　Ni-foam　(0.001　min(-1))　and　commercial　Pd/C　(0.010　min(-1)),　respectively.　The　excellent　electrocatalysis　for　FLO　dechloridation　of　Pd@Ni-foam　cathode　is　ascribed　to　the　3D　self-supported　Ni-foam　frame　for　mass　transfer　enhancement　and　the　formation　of　Pd-Ni　micro-interfaces　leading　to　the　high　utilization　of　atomic　H*.　Furthermore,　the　toxicity　assessment　showed　that　the　antibacterial　activity　of　FLO　was　complete　elimination　after　electrocatalytic　dechlorination　process.