Aiming　at　the　characteristics　of　thinking　centric　studies,　Brain　Informatics　(BI)　emphasizes　on　a　systematic　approach　to　investigate　human　information　processing　mechanisms.　Systematic　human　brain　data　management　is　the　basic　of　BI　methodology.　It　needs　to　realize　not　only　the　storage　and　data　publishing　oriented　management,　but　also　the　systematic　analysis　oriented　management.　However,　the　traditional　brain　databases　cannot　effectively　support　such　a　systematic　human　brain　data　management.　In　this　paper,　we　propose　a　Data-Brain　based　framework,　Global　Learning　Scheme　for　BI　(GLS-BI),　to　dynamically　integrate　BI　data　and　analytical　resources　for　realizing　the　systematic　analysis　oriented　brain　data　management.　The　GLS-BI　offsets　the　disadvantages　of　the　existing　brain　databases　and　provides　a　practical　approach　towards　the　systematic　human　brain　data　management.　©　Springer-Verlag　Berlin　Heidelberg　2010.