The　capability　of　structure　resisting　progressive　collapse　depends　on　controlling　the　dispersion　of　damage　by　uncommon　agency　in　the　part　of　the　structure　and　to　avoid　the　destruction　just　likes　the　Domino　action.　For　the　RC　frame,　when　one　column　under　the　beams　is　broken,　the　key　to　avoid　progressive　collapse　is　whether　the　frame　beams　can　bear　the　column＇s　load　to　produce　a　new　way　for　transmitting　the　force　or　not.　In　this　paper,　according　to　the　present　design　code,　the　numerical　analysis　was　carried　out　for　researching　the　vertical　progressive　collapse　of　a　six-story　building　by　finite　element　software-ADINA.　The　collapse　stress　and　flexibility　of　frame　structure　under　blast　action　could　be　obtained,　which　meet　current　design　code　and　can　provide　references　for　further　study　on　collapse　mechanism　and　anti-blasting　measures.　©2010　IEEE.