One　example　of　grid　reconstruction　and　blood　flow　simulation　for　a　patient　with　internal　carotid　artery　aneurysms　was　presented.　The　method　accurately　duplicates　the　geometry　to　provide　computer　simulations　of　the　blood　flow.　Initial　images　were　obtained　by　using　CT　angiography　in　DICOM　format.　The　image　was　processed　by　using　MIMICS　software,　and　the　3D　fluid　model　(blood　flow)　and　3D　solid　model　(wall)　were　generated.　The　subsequent　output　was　exported　to　the　Ansys　workbench　software　to　generate　the　volumetric　mesh　for　further　homodynamic　study.　The　fluid　model　was　defined　and　simulated　in　CFX　software,　while　the　solid　model　was　calculated　in　ANSYS　software.　The　force　data　calculated　firstly　in　the　CFX　software　were　transferred　to　ANSYS　software,　and　after　receiving　the　force　data,　total　mesh　displacement　data　were　calculated　in　Ansys　software.　Then　the　mesh　displacement　data　were　transferred　back　to　CFX　software.　The　data　exchange　was　processed　in　workbench　software.　The　results　of　simulation　could　be　visualized　in　CFX-post.　The　wall　shear　stress,　wall　total　pressure　and　von　mises　stress　were　in　good　agreement　with　the　clinical　and　pathological　practice.　The　results　of　this　study　play　an　important　role　in　the　formation,　growth,　rupture　and　prognosis　of　an　aneurysm　on　clinic　application,　and　maybe　a　practical　tool　for　planning　treatment　and　follow-up　of　patients　after　neurosurgical　or　endovascular　interventions　with　3D　angiography.　©　2010　IEEE.