With　the　rapid　development　of　the　globalization　of　economy,　internationalization　of　S&T　and　socialization　of　information,　the　internationalization　of　technology　innovation　which　characterized　by　the　research　and　development　(R&D)　internationalization　has　been　the　new　pattern　of　technology　cooperation　and　innovation　for　country,　region　and　enterprise,　and　also　has　been　the　source　of　the　sustainable　development　of　the　economy.　From　the　perspective　of　developing　country,　this　paper　conducts　a　systematic　and　comprehensive　analysis　of　the　determinants　of　oversea　R&D　investment　and　location　choice　by　multinationals　applying　the　Motivation-behavior　analytical　paradigm.　Our　findings　reinforce　the　conclusions　that　supply　factors　have　played　an　important　and　growing　role　in　influencing　a　company＇s　foreign　R&D　decision　in　developing　countries;　and　then,　explain　the　discrepancy　of　R&D　internationalization　across　regions　and　sectors;　finally,　we　conduct　a　analysis　and　prediction　of　the　development　trends　of　R&D　internationalization.　©2009　IEEE.