Hiv-1　integrase　(IN)　is　an　important　and　validated　target　for　drug　design.　The　diketo　acid　(DKA)　compounds　were　identified　as　potent　inhibitors　for　IN.　Due　to　the　IN-5citep　complex　structure　has　been　resolved,　it　can　give　hints　for　IN-DKAs　binding　mode.　A　comprehensive　receptor　based　pharmacophore　model　based　on　the　reasonable　binding　mode　is　feasible　for　developing　new　and　better　inhibitors.　In　this　report,　8　effective　carbazolone-containing　and　8-hydroxy-[1,6]　naphthyridine-containing　α,⌈-diketo　acid　inhibitors　were　docked　to　IN,　respectively.　Then,　receptor-based　pharmacophore　models　were　generated　according　to　the　structural　constraints　of　IN　and　the　interactive　features　between　IN　and　inhibitors.　We　attempted　to　refine　the　obtained　pharmacophore　models　according　to　the　corresponding　residues　of　IN　around　pharmacophore　features.　Finally,　The　common　features　were　obtained　by　comparing　the　pharmacophore　models　obtained　above　with　a　pharmacophore　model　generated　based　on　MK-0518.　The　common　features　coexisted　in　diverse　skeleton　ligand　structures　and　receptor-ligand　interactions　indicate　the　essential　interactions　between　IN　and　DKA　inhibitors　reliably.　The　results　obtained　above　are　helpful　for　us　to　rationally　design　and　synthesize　new　potential　DKA　IN　inhibitors.　©2009　IEEE.