For　the　difference　of　iron　and　manganiferous　groundwater　qualities　and　spatial　distribution　between　the　groundwater　sources　and　service　regions,　different　layout　of　groundwater　biological　removal　of　iron　and　manganese　system　should　be　adopted.　It　was　one　of　the　conditions　to　prevent　the　ferromanganese　sediment　silting　raw　water　pipelines　to　ensure　the　service　lives　of　water　pipelines.　It　was　important　for　the　security　and　stability　runing　of　the　entire　water　supply　system.　In　this　paper,　the　layout　relationship　between　the　groundwater　biological　removal　of　iron　and　manganese　system　and　the　water　supply　network　were　studied.　As　following　recommendations　had　been　made:　1,　to　minimize　the　oxygenation　opportunity　in　the　process　of　iron　and　manganiferous　groundwater　be　taken　and　delivered;　2,　to　take　into　account　of　removal　of　iron　and　manganese　water　works　should　be　as　close　as　possible　to　water　source　during　the　establishment　of　the　taking　water,　purification　and　delivery　of　water　systems,　in　order　to　reduce　the　length　of　transmission　of　water　line.　Use　of　these　recommendations　in　practice,　achieved　good　results:　the　groundwater　biological　removal　of　iron　and　manganese　treatment　plant　had　a　daily　handling　capacity　of　200,000　tons　and　the　effluent　iron,　manganese　all　was　trace　amount　and　met　the　Chinese　standards　for　drinking　water　quality.　©　2009　ASCE.