The　pathological　reason　for　schizophrenia　is　still　unknown　to　date.　Fortunately,　deformation　based　morphometry　(DBM)　provides　an　important　tool　for　the　computational　anatomy　research.　In　this　study　we　detected　the　changes　of　regional　volume　in　brain　structures　between　the　first　episode　schizophrenia　(FES)　and　normal　controls　with　DBM　method.　Information　of　the　difference　is　derived　from　the　deformation　field　acquired　during　HAMMER　non-rigid　registration.　The　experimental　results　show　that　contracted　regions　are　mainly　located　in　Brodmann42　and　right　occipital　lobe　while　the　expanded　regions　are　located　in　Brodmann38,　21,　left　middle　frontal　gyrus　and　left　cerebellum.　This　research　is　very　helpful　to　make　the　cause　of　changes　in　schizophrenia＇s　brain　structures　clear.　©　2008　IEEE.