The　application　of　microfluidic　lab-on-a-chip　platform　in　different　areas　requires　higher　degree　of　flexibility　of　the　supporting　platform　to　facilitate　the　design　and　integration　of　the　microfluidic　chip.　Here,　a　programmable　thermal　controlling　array　is　proposed　for　generation　of　arbitrary　patterns　of　thermal　profiles　that　provides　proper　temperature　environment　for　a　wider　range　of　lab-on-a-chip　applications.　This　array　is　the　integration　of　an　array　of　thermal　actuators　and　an　array　of　thermal　sensors,　each　can　be　driven　and　addressed　individually.　This　platform　win　contribute　to　the　on　chip　integration　of　bio/chemical　analysis　and　molecular　diagnostics.　©　2007　IEEE.