With　the　rapid　development　of　information　technology,　we　are　experiencing　the　globalization　of　business　processes　and　accompanying　Information　Systems　(IS).　The　utilization　and　implementation　of　various　IS　substantially　contributed　to　the　feasibility　of　globalization.　However,　it　is　a　great　challenge　to　manage　IS　in　a　global　environment,　because　managers　have　to　deal　with　the　differences　of　various　countries.　Based　on　literature　study,　we　clarified　the　concept　and　contents　of　Internationalized　Information　Systems　Management　(IISM)　and　identified　seven　significant　management　issues　for　IISM,　namely　policy,　legislation,　economy,　language,　organization,　technology　and　national　culture.　Subsequently,　those　management　issues　were　analyzed　in　detail　and　the　further　research　was　recommended　briefly.