Haematopoietic　cytokines　are　important　in　the　regulation　of　haematopoiesis　and　immune　responses,　and　they　can　also　influence　lymphocyte　development.　Hundreds　of　members　of　several　different　cytokines　families　have　been　discovered　by　some　different　methods.　But　fast　evolution　rate　and　low　similarity　of　cytokines　prevent　identifing　novel　members　of　a　cytokine　family　completely　with　classical　tools　such　as　BLAST.　Here　hidden　markov　model　algorithm　is　performed　on　Haematopoietic　cytokines　and　inerleukin　10　(IL10)　related　family,　and　two　motifs　are　discovered.　Then,　three　famous　protein　sequence　databases(SwissProt,　IPI　and　Nr)　were　scanned　using　each　motif　respectively,　which　leaded　to　evaluate　the　relation　between　motif　and　every　sequence　of　database　including　some　unknown　proteins　or　some　ambiguous　function　proteins　of　known　families.　Furthermore,　the　biology　features　were　compared　to　filter　novel　members　of　cytokines.　As　a　result,　four　proteins　are　predicted　to　be　the　cytokine　candidates.　©　2005　IEEE.