Due　to　the　advantages　of　degradability　and　excellent　biocompatibility,　the　biodegradable　alloy　stents,　are　expected　to　be　the　promising　solution　for　the　problems　such　as　the　restenosis　of　the　permanent　stents,　the　late　stents　thrombosis　of　drug　eluting　stents,　leading　the　fourth　generation　of　innovation　in　the　field　of　the　cardiovascular　interventional　therapy.　However,　insufficient　scaffold　performance　and　too　short　degradation　time　are　the　main　limitations　for　the　biodegradable　stents　in　clinical　application　currently.　To　deal　with　these　problems,　stent　design　and　optimization　can　be　an　effective　method　to　improve　scaffold　performance　of　biodegradable　stents　and　prolong　their　service　time.　Structure　design　and　optimization　of　biodegradable　stents　is　a　complex　process　involving　balance　of　different　mechanical　performances,　hemodynamics　and　the　changing　of　scaffold　performance　in　corrosion　environment:　Therefore,　in　this　article,　the　state-of-the-art　design　and　optimization　of　the　biodegradable　stents　were　reviewed　and　the　challenges　and　future　research　directions　were　pointed　out.　©　2019　Chinese　Academy　of　Medical　Sciences.　All　Rights　Reserved.