The　profile　of　globoidal　indexing　cam　is　spatial　undevelopable　surface.　It　needs　special　CNC　machine　tool　to　finish　batch　production.　The　machining　quality　of　the　profile　of　globoidal　indexing　cam　could　be　affected　by　the　movement　error　of　each　part　of　machine　tool　and　the　clamped　positioning　error　of　workpiece.　Firstly,this　paper　analyses　the　systematic　error　of　the　special　machine　tool　of　globoidal　cam,　derives　the　error　transfer　matrix,　establishes　the　mathematical　model　of　the　globoidal　cam　profile　which　including　all　machining　system　errors　through　multi-body　system　theory　primarily.　Secondly,　it　analyzes　the　influence　caused　by　each　machine　tool　error　and　calculates　the　influence　coefficient　of　machine　tool　errors.　Finally,　it　simulates　the　influence　of　each　error　on　the　transmission　accuracy　of　globoidal　cam　mechanism.　This　paper　lays　a　theoretical　foundation　for　the　distribution　of　machine　errors　and　the　error　detection,　the　error　evaluation　and　the　error　tracing　of　globoidal　cam　profile.　©　2019　Int.　J.　Mech.　Eng.　Rob.　Res.