BackgroundHemodynamic　characteristics　of　the　interaction　influence　among　support　level　and　model　of　LVAD,　and　coupling　-blocker　has　not　been　reported.MethodsIn　this　study,　the　effect　of　support　level　and　model　of　LVAD　on　cardiovascular　hemodynamic　characteristics　is　investigated.　In　addition,　the　effect　of　-blocker　on　unloading　with　LVAD　is　analyzed　to　elucidate　the　mechanism　of　LVAD　coupling　-blocker.　A　multi-scale　model　from　cell　level　to　system　level　is　proposed.　Moreover,　LVAD　coupling　-blocker　has　been　researching　to　explain　the　hemodynamics　of　cardiovascular　system.ResultsMyocardial　force　was　decreased　along　with　the　increase　of　support　level　of　LVAD,　and　co-pulse　mode　was　the　lowest　among　the　three　support　modes.　Additionally,　the　-blocker　combined　with　LVAD　significantly　reduced　the　left　ventricular　volume　compared　with　LVAD　support　without　-blocker.　However,　the　left　ventricular　pressure　under　both　cases　has　no　significant　difference.　External　work　of　right　ventricular　was　increased　along　with　the　growth　of　support　level　of　only　LVAD.　The　LVAD　under　co-pulse　mode　achieved　the　lowest　right-ventricular　EW　among　the　three　support　modes.ConclusionsCo-pulse　mode　with　-blocker　could　be　an　optimal　strategy　for　promoting　cardiac　structure　and　function　recovery.