Freeway　landscape　design　is　closely　related　to　driver　performance.　How　to　stimulate　drivers＇　positive　physiological　condition　and　improve　overall　driving　performance　by　adopting　ideal　landscape　design　has　become　a　research　interest　in　recent　years.　This　study　explores　the　impact　of　changing　the　landscape　pattern　at　appropriate　intervals　on　driver　fatigue　and　negative　mental　workload.　Drivers＇　mental　performance　was　evaluated　under　three　types　of　spatial　patterns:　open,　semi-open,　and　vertical.　Thirty　drivers,　15　Type　A　Behavior　Pattern　(TABP)　and　15　Type　B　Behavior　Pattern　(TBBP)　drivers,　respectively,　were　recruited　to　conduct　the　driving　simulator　experiment.　Data　on　drivers＇　physiological　variation　trends　show　that　the　mental　workload　of　TABP　and　TBBP　drivers　varied　under　different　spatial　patterns.　The　principal　factor　high　frequency　(HF)　was　used　to　investigate　the　distance　threshold　for　different　freeway　landscape　patterns　based　on　the　analysis　of　physiological　data　collected　by　electrocardiogram　(ECG).　This　study　reveals　that　changing　landscape　pattern　at　a　certain　interval　can　benefit　drivers＇　physical　and　mental　status.　It　is　suggested　that,　when　the　design　speed　is　100　km/h,　changing　landscape　pattern　every　11　km　can　reduce　fatigue　and　improve　driving　performance　in　both　TABP　and　TBBP　drivers.　The　conclusions　of　this　study　provide　a　rationale　and　guidance　for　agencies　to　adopt　different　spatial　patterns　in　future　freeway　landscape　design.