Anticancer　metallodrugs　that　aim　to　physiological　characters　unique　to　tumor　microenvironment　are　expected　to　combat　drug　tolerance　and　side-effects.　Recently,　owing　to　the　fact　that　reactive　oxygen　species＇　is　closely　related　to　the　development　of　tumors,　people　are　committed　to　developing　metallodrugs　with　the　capacity　of　improving　the　level　of　reactive　oxygen　species　level　toinduce　oxidative　stress　in　cancer　cells.　Herein,　we　demonstrated　that　peptide　templated　gold　clusters　with　atomic　precision　preferably　catalyze　the　transformation　of　hydrogen　peroxide　into　superoxide　anion　in　oxidative　pressure-type　tumor　cells.　Firstly,　we　successfully　constructed　gold　clusters　by　rationally　designing　peptide　sequences　which　targets　integrin　alpha(v)beta(3)　overexpressed　on　glioblastoma　cells.　The　superoxide　anion,　radical　derived　from　hydrogen　peroxide　and　catalyzed　by　gold　clusters,　was　confirmed　in　vitro　under　pseudo-physiological　conditions.　Then,　kinetic　parameters　were　evaluated　to　verify　the　catalytic　properties　of　gold　clusters.　Furthermore,　these　peptide　decorated　clusters　can　serve　as　special　enzyme-like　catalyst　to　convert　endogenous　hydrogen　peroxide　into　superoxide　anion,　elevated　intracellular　reactive　oxygen　species　levels,　lower　mitochondrial　membrane　potential,　damage　biomacromolecules,　and　trigger　tumor　cell　apoptosis　consequently.