The　traffic　guide　sign　plays　an　important　role　in　the　traffic　sign　system.　In　order　to　improve　drivers＇　visual　cognition　of　regional　signs　at　intersections　of　highways　and　urban　roads,　this　paper　designs　three　kinds　of　traffic　signs　and　compares　them　with　the　existing　signs.　Based　on　the　change　of　driving　behavior　in　the　driving　simulation　experiment　and　the　results　of　the　questionnaire　survey　after　driving,　this　paper　adopts　the　grey　approximate　optimal　model　to　comprehensively　evaluate　the　designed　three　kinds　of　signs　and　the　existing　signs.　Combining　15　subjective　and　objective　indicators,　scheme　2　has　the　highest　evaluation　score.　Thus,　the　driver　tends　to　have　the　information　of　road　name　and　intersection　road　direction　and　the　path　guidance　sign　of　proximal　information　and　remote　information.　The　paper　provides　a　certain　basis　for　the　traffic　guide　sign　setting　in　the　connecting　area　of　highways　and　urban　road.　©　ASCE.