N-aminoethyl　piperazine　propane　sulfonate　(AEPPS)　modified　multi-walled　carbon　nanotubes　(MWCNTs)　(AEPPS-PD@MWCNTs)　were　prepared　by　co-deposition　of　dopamine　and　AEPPS　on　MWCNTs　surfaces.　AEPPS-PD@MWCNTs　were　mixed　with　piperazine　aqueous　solution　and　polymerized　with　1,3,5-benzenetricarboxylic　chloride　(TMC,　dissolved　in　hexane　solution)　to　prepare　negatively　charged　NF　membranes,　which　were　characterized　by　Fourier　Transform　Infrared　Spectroscopy,　X-ray　Photoelectron　Spectroscopy,　Transmission　Electron　Microscopy　and　Atomic　Force　Microscopy.　It　was　found　that　compatibility　between　AEPPS-PD@MWCNTs　and　polyamide　matrix　was　enhanced　as　a　result　of　the　multiple　interactions　between　AEPPS-PD@MWCNTs　and　TMC　monomers.　At　optimized　conditions,　pure　water　permeability　of　hybrid　membrane　was　127.3　L　m(-2)　h(-1)　MPa-1,　1.8　times　as　high　as　pristine　PIP/TMC　membrane　without　compromising　Na2SO4　rejection.　Meanwhile,　NaCI　rejection　of　hybrid　membrane　was　19.0%,　much　lower　than　pristine　PIP/TMC　membrane.　Hybrid　membrane　exhibited　applications　in　separation　of　monovalent/divalent　salts　and　monovalent　salts/neutral　organics　coupled　with　good　stability　and　better　anti-fouling　property　which　was　sought　for　applications　in　the　field　of　desalination,　food　and　biological　separation　processes.