This　paper　presented　an　experimental-computational　approach　to　investigate　compressive　strength　of　magnesium　phosphate　cement　(MPC)　with　nanoindentation　technique　and　finite　element　analysis.　Firstly,　the　compressive　strength,　macroscopic　elastic　modulus,　porosity,　microscopic　elastic　modulus,　chemical　compositions　and　contents　of　the　MPC　were　tested　by　press,　MIP,　nanoindentation,　XRD　and　SEM-EDS.　Secondly,　the　microscopic　elastic　modulus　of　magnesium　potassium　phosphate　hexahydrate　(MKP)　and　magnesium　oxide　(MgO)　as　the　components　of　the　MPC　were　calculated　by　homogenization　method.　Then,　the　MPC　was　scanned　by　X-ray　Computed　Tomography　(X-CT)　to　obtain　the　3D　structure　adopted　as　the　finite　element　model.　Finally,　the　input　parameters　of　the　model　were　calibrated　based　on　the　results　of　homogenization　and　the　modified　constitutive　relations　to　simulate　the　uniaxial　compression　test　of　the　MPC.　It　was　found　that　the　simulated　load-displacement　results　were　in　good　agreement　with　the　experimental　results.　(C)　2018　Elsevier　Ltd.　All　rights　reserved.