To　improve　the　stability　of　Pd-based　catalysts　at　high　temperatures,　we　herein　report　a　novel　strategy　of　first　incorporating　Pd　to　the　lattice　of　three-dimensionally　ordered　macroporous　La0.6Sr0.4MnO3　(3DOM　LSMO)　and　then　depositing　Pd　nanoparticles　(NPs)　on　the　surface　of　3DOM　LSMO　directly　by　in-situ　reducing　3DOM　La0.6Sr0.4Mn1-xPdxO3　(3DOM　LSMPdxO).　Physicochemical　properties　of　the　materials　were　characterized　by　means　of　numerous　techniques,　and　their　catalytic　activities　were　evaluated　for　the　combustion　of　methane.　Compared　to　the　Pd-free　sample,　the　doping　of　Pd　was　beneficial　for　improvement　in　catalytic　activity,　and　the　3DOM　LSMPd0.04O　sample　performed　the　best　(T-50%　=　458　degrees　C　and　T-90%　=　550　degrees　C　at　a　space　velocity　of　40,000　mL/(g　h)).　The　in-situ　reduction　of　the　Pd-doped　samples　could　generate　the　yPd/3DOM　LSMO　(y　=　1.18-2.57　wt%)　catalysts　that　exhibited　good　thermal　stability　and　SO2-tolerant　ability　although　their　catalytic　activities　slightly　decreased　as　compared　to　that　prepared　by　the　traditional　impregnation　method.　The　slight　drop　in　activity　of　yPd/3DOM　LSMO　was　due　to　the　partial　destroy　of　the　LSMO　perovskite　after　reduction　at　500　degrees　C.　Among　the　Pd/3DOM　LSMO　samples,　1.18Pd/3DOM　LSMO　showed　the　best　thermal　stability　and　SO2-tolerant　ability,　which　was　attributed　to　the　strong　interaction　between　Pd　NPs　and　3DOM　LSMO.