\　Traditional　clinical　mode　of　enhanced　external　counterpulsation　is　not　targeted　for　different　diseases.　Specialized　strategies　in　the　treatment　of　enhanced　external　counterpulsation　for　coronary　heart　disease　and　cerebral　ischemic　stroke　are　supposed　to　be　distinguished.　The　goal　of　treatment　for　coronary　heart　disease　is　diastolic　blood　pressure/systolic　blood　pressure=Q1.2　after　counterpulsation,　while　the　goal　of　treatment　for　cerebral　ischemic　stroke　is　the　improvement　of　mean　arterial　pressure.　A　computational　lumped　parameter　model　was　established　for　the　simulation　of　hemodynamic　effect　of　enhanced　external　counterpulsation　on　two　diseases.　Vessel　collapse　was　considered　during　the　simulation　of　counterpulsation.　Based　on　different　pressurized　and　decompressed　rate,　pressurized　moment,　pressure　duration,　and　pressure　amplitude,　different　counterpulsation　modes　were　applied　to　the　model　and　the　immediate　hemodynamic　effects　were　compared.　Results　showed　that　the　pressure　duration　and　pressure　amplitude　had　most　influence　on　two　diseases.　For　cerebral　ischemic　stroke,　the　longer　pressure　duration　and　the　higher　pressure　amplitude　of　thighs,　the　higher　mean　arterial　pressure;　while　for　coronary　heart　disease,　the　value　of　Q　was　highest　when　the　pressure　end　moment　was　0.6s　during　a　0.88-s　cardiac　cycle,　and　Q　had　a　linear　increase　in　the　pressure　amplitude　of　buttocks,　but　little　change　with　the　increase　of　calves　and　thighs　pressure　amplitude.　For　patients　with　coronary　heart　disease,　the　pressure　duration　was　not　supposed　to　be　too　long　to　avoid　the　increase　of　systolic　blood　pressure,　and　the　improvement　of　pressure　amplitude　of　buttocks　could　promise　a　positive　treatment　effect　for　coronary　heart　disease.　While　for　patients　with　cerebral　ischemic　stroke,　both　the　long　pressure　duration　of　each　part　and　the　high　pressure　amplitude　of　thighs　could　result　in　the　systolic　blood　pressure　and　diastolic　blood　pressure　have　a　certain　increase,　thus　promoting　the　maximum　mean　arterial　pressure　and　a　best　treatment.