Motion　compensation　is　the　key　technique　to　reduce　temporal　redundancy　in　video　coding.　Interpolation　filters　are　adopted　to　generate　the　inter　frame　prediction　for　motion　compensation　with　fractional　pixel　accuracy.　In　existing　video　coding　standards　such　as　H.264/AVC　and　HEVC,　a　set　of　predefined　interpolation　filters　is　adopted　in　motion　compensation.　However,　predefined　interpolation　filters　cannot　adapt　to　the　video　content,　which　may　compromise　the　coding　efficiency.　In　this　paper,　a　content　adaptive　interpolation　scheme　is　proposed　for　motion　compensation.　In　the　proposed　scheme,　a　set　of　adaptive　interpolation　filters　is　derived　for　each　frame　as　additional　interpolation　filters　to　minimize　the　inter　prediction　difference.　Rate-distortion　optimization　is　employed　to　choose　between　the　predefined　interpolation　filters　and　the　derived　adaptive　interpolation　filters　to　achieve　the　best　coding　performance　at　the　low　bit　rates.　The　proposed　scheme　is　implemented　into　the　HM　12.1　software.　Experimental　results　show　that　the　proposed　scheme　achieves　5.13　percent,　3.42　percent　and　4.07　percent　bit　rate　saving　on　average　compared　with　HEVC　under　the　＂low　delay　P＂,　the　＂low　delay　B＂　and　the　＂random　access＂　configurations　respectively.　(C)　2018　Elsevier　Inc.　All　rights　reserved.