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作者:

Lin, Lan (Lin, Lan.) | Fu, Zhenrong (Fu, Zhenrong.) | Jin, Cong (Jin, Cong.) | Tian, Miao (Tian, Miao.) | Wu, Shuicai (Wu, Shuicai.) (学者:吴水才)

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摘要:

The small-world architecture has gained considerable attention in anatomical brain connectivity studies. However, how to adequately quantify small-worldness in diffusion networks has remained a problem. We addressed the limits of small-world measures and defined new metric indices: the small-world efficiency (SWE) and the small-world angle (SWA), both based on the tradeoff between high global and local efficiency. To confirm the validity of the new indices, we examined the behavior of SWE and SWA of networks based on the Watts-Strogatz model as well as the diffusion tensor imaging (DTI) data from 75 healthy old subjects (aged 50-70). We found that SWE could classify the subjects into different age groups, and was correlated with individual performance on the WAIS-IV test. Moreover, to evaluate the sensitivity of the proposed measures to network, two network attack strategies were applied. Our results indicate that the new indices outperform their predecessors in the analysis of DTI data.

关键词:

Connectome DTI Brain network Small world

作者机构:

  • [ 1 ] [Lin, Lan]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, Beijing 100124, Peoples R China
  • [ 2 ] [Fu, Zhenrong]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, Beijing 100124, Peoples R China
  • [ 3 ] [Tian, Miao]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, Beijing 100124, Peoples R China
  • [ 4 ] [Wu, Shuicai]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, Beijing 100124, Peoples R China
  • [ 5 ] [Jin, Cong]Capital Med Univ, Beijing Friendship Hosp, Med Engn Dept, Beijing 100050, Peoples R China

通讯作者信息:

  • [Lin, Lan]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, Beijing 100124, Peoples R China

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来源 :

EXPERIMENTAL BRAIN RESEARCH

ISSN: 0014-4819

年份: 2018

期: 10

卷: 236

页码: 2677-2689

2 . 0 0 0

JCR@2022

ESI学科: NEUROSCIENCE & BEHAVIOR;

ESI高被引阀值:189

JCR分区:4

被引次数:

WoS核心集被引频次: 9

SCOPUS被引频次: 10

ESI高被引论文在榜: 0 展开所有

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