To　provide　the　significance　factors　of　2　450　MHz　microwave　ablation　temperature　field　model　at　different　times　and　different　positions,　a　microwave　finite　element　model　was　established　according　to　the　electromagnetic　equation　and　the　biological　heat　transfer　equation.　The　variances　of　the　model　parameters　such　as　density　(ρ),　specific　heat　capacity　(c),　convective　exchange　coefficient　(h),　conductivity　(σ),　thermal　conductivity　(K)　and　relative　dielectric　constant　(ε)　were　then　calculated　to　obtain　the　contribution　rate　(SS)　and　main　effect.　Results　show　that　the　water　cooling　effect　of　microwave　antenna　has　certain　influence　on　the　temperature　of　the　center　point,　SS　was　about　0.09,　but　has　no　effect　on　the　near　field　and　the　far　field　temperature.　In　the　near　field　region　on　water-cooled　side,　c　and　σ　have　significant　effects　on　the　temperature　field　during　the　early　stage　of　ablation,　and　the　influences　of　K　and　σ　are　higher　in　the　later　session.　In　the　near　field　region　with　no　cooled　water,　the　influences　of　the　electrical　parameters　on　the　temperature　increases　with　the　simulation　time,　and　the　effect　of　c　decreases　gradually,　and　the　effect　of　K　is　always　small.　In　the　far　field　region,　the　temperature　changes　are　caused　by　the　interaction　of　the　model　parameters,　and　the　sensitivity　of　the　parameters　is　very　similar.　According　to　the　main　effect　analysis,　the　temperature　is　positively　correlated　with　σ,　and　is　negatively　correlated　with　c,　ρ,　h.　Moreover,　the　correlation　between　the　temperature　and　K,　ε　varies　with　time　and　position.　Therefore,　the　parameter　research　based　on　variance　analysis　can　provide　scientific　and　reliable　reference　for　the　specificity　analysis　of　the　ablation　models,　and　model　parameters　have　the　special　sensitivity　especially　for　the　near　field　temperature　at　different　time.　According　to　the　analysis　results　in　the　near　region　on　water-cooled　side,　the　model　parameters　can　be　adjusted　by　feedback,　and　the　temperature　field　simulation　results　with　a　high　precision　can　be　obtained.　©　2018,　Editorial　Department　of　Journal　of　Beijing　University　of　Technology.　All　right　reserved.