Objective　To　explore　the　effect　of　different　initial　state　setting　on　a　valve　simulation.　Methods　Two-dimensional　structural　models　were　established　with　the　initial　state　of　the　aortic　valve　being　partially　closed　in　one　model　and　fully　opened　in　the　other.　The　time-dependent　load　was　applied　to　the　valve　and　the　vessel　wall　of　the　aortic　and　the　ventricle　sides.　The　finite　element　method　was　used　to　study　the　maximum　stress,　the　length　of　the　joint,　and　the　contact　force　of　the　closed　aortic　valve　under　two　different　initial　states.　Results　The　stress　and　contact　force　of　the　aortic　valve　were　relatively　large　at　the　closed　position　when　the　initial　state　was　fully　opened.　The　closure　degree　of　the　valve　was　low,　and　the　variations　in　stress　and　closure　degree　were　large　during　the　periodic　cycle.　The　stress　and　contact　force　of　the　valve　were　relatively　small　when　the　aortic　valve　was　partially　closed.　The　closure　degree　was　high,　and　the　variations　in　stress　and　closure　degree　of　the　aortic　valve　were　small　during　the　periodic　cycle.　Conclusions　In　the　case　of　the　aortic　valve　partially　closed　in　the　initial　state,　the　stability　of　the　calculation　process　and　the　closure　degree　of　the　valve　were　relatively　high,　which　should　be　given　more　consideration　in　numerical　simulation.　The　results　can　be　used　to　study　the　mechanical　behavior　of　the　valve　and　the　biomechanical　mechanism　of　the　aortic　root.　Copyright　©　2018　by　the　Editorial　Board　of　Journal　of　Medical　Biomechanics.