Objective　To　establish　chronic　coronary　stenosis　model　for　fractional　flow　reserve　derived　from　coronary　CT　angiography　(FFR　CT　)　in　Bama　miniature　pig,　and　to　evaluate　its　reliability.　Methods　Sixteen　Bama　miniature　pigs　were　used　to　establish　chronic　coronary　stenosis　models　through　placing　Ameroid　constrictor　into　proximal　or　middle　segments　of　left　anterior　descending　arteries　(LAD).　In　the　2nd　week　after　modeling,　the　degrees　of　stenosis　were　monitored　with　coronary　CTA.　Invasive　coronary　angiography　was　used　to　verify　stenosis　degrees　and　measure　fractional　flow　reserve　(FFR)　within　2　days　of　last　coronary　CTA　examination.　Computational　fluid　dynamics　model　was　constructed　and　FFR　CT　was　calculated　by　the　specialized　laboratory　based　on　coronary　CTA　data　respectively.　Simulated　FFR　CT　and　FFR　values　were　compared　to　verify　this　model.　Results　Models　were　successfully　established　in　10　pigs　with　a　total　of　24　coronary　CT　examinations,　of　which　image　quality　met　the　diagnostic　requirements.　All　models　were　with　LAD　stenosis<25%　in　the　2nd　week　after　operation.　LAD　stenosis　>50%　was　found　in　the　3rd　week　in　9　pigs,　and　the　other　one　was　found　with　LAD　stenosis　>50%　in　the　4th　week.　The　results　of　coronary　CTA　corresponded　to　those　of　coronary　angiography.　There　was　no　significant　difference　between　simulated　FFR　CT　and　FFR　value　(t=-1.13,　P=0.29).　Conclusion　Through　placing　Ameroid　constrictor　into　LAD　of　Bama　miniature　pig　and　monitoring　the　degree　of　stenosis　with　coronary　CTA,　model　of　chronic　coronary　stenosis　could　be　successfully　established,　which　are　suitable　for　noninvasive　simulating　hemodynamics　study　based　on　coronary　CTA.　Copyright　©　2018　by　the　Press　of　Chinese　Journal　of　Medical　Imaging　and　Technology.