A　series　of　immobilized　bipyridine-proline　based　on　mesoporous　silica　with　different　structures　were　synthesized　via　grafting　followed　by　coordination　method.　All　catalysts　were　used　in　asymmetric　aldol　reaction　of　cyclohexanone　with　4-nitrobenzaldehyde,　and　their　catalytic　performance　including　activities　and　stabilities　have　been　investigated.　The　results　indicated　that　the　pore　structure,　morphology,　and　even　the　particle　dispersity　all　showed　the　effects　on　the　catalytic　performance　of　immobilized　catalysts.　[GRAPHICS]　.