The　hollow　Fe3O4　/mesoporous　SiO2/TiO2　(FST)　composite　microspheres　were　prepared　with　the　multistep　coating　technique　through　sol-gel　and　hydrothermal　process.　The　composite　microspheres　have　a　unique　a　network　hollow　structure　intersected　with　Fe3O4　nanorods,　mesoporous　SiO2　interlayer　and　TiO2　nanoparticles.　The　magnetization　saturation　and　coercivity　values　of　the　FST　microspheres　are　9.4　emu/g　and　45.98　Oe　so　that　the　composite　microspheres　could　be　effectively　separated　from　the　suspension　by　an　external　magnetic　field　and　redispersed　for　further　reuse.　The　as-synthesized　FST　microspheres　show　a　high　surface　area　(338　m(2)/g)　and　a　large　pore　volume　(0.44　cm(3)/g).　The　FST　microspheres　exhibit　high　photocatalytic　activity　under　the　UV　light,　and　the　degradation　rate　of　methyl　orange　could　reach　up　to　95.0%.　It　is　important　that　the　hollow　structure　and　anatase　TiO2　nanoparticles　in　mesoporous　channels　are　both　attributed　to　the　enhanced　photocatalytic　performance　of　the　FST　photocatalyst.