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作者:

Li, Wan (Li, Wan.) | Yang, Chunlan (Yang, Chunlan.) | Shi, Feng (Shi, Feng.) | Wang, Qun (Wang, Qun.) (学者:王群) | Wu, Shuicai (Wu, Shuicai.) (学者:吴水才) | Lu, Wangsheng (Lu, Wangsheng.) | Li, Shaowu (Li, Shaowu.) | Nie, Yingnan (Nie, Yingnan.) | Zhang, Xin (Zhang, Xin.)

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摘要:

Normal aging has been linked with the decline of cognitive functions, such as memory and executive skills. One of the prominent approaches to investigate the age-related alterations in the brain is by examining the cortical brain connectome. IBASPM is a toolkit to realize individual atlas-based volume measurement. Hence, this study seeks to determine what further alterations can be revealed by cortical brain networks formed by IBASPM-extracted regional gray matter volumes. We found the reduced strength of connections between the superior temporal pole and middle temporal pole in the right hemisphere, global hubs as the left fusiform gyrus and right Rolandic operculum in the young and aging groups, respectively, and significantly reduced inter-module connection of one module in the aging group. These new findings are consistent with the phenomenon of normal aging mentioned in previous studies and suggest that brain network built with the IBASPM could provide supplementary information to some extent. The individualization of morphometric features extraction deserved to be given more attention in future cortical brain network research.

关键词:

Graph theory IBASPM Cortical brain network Normal aging Regional gray matter volume

作者机构:

  • [ 1 ] [Li, Wan]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 2 ] [Yang, Chunlan]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 3 ] [Wu, Shuicai]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 4 ] [Nie, Yingnan]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 5 ] [Zhang, Xin]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 6 ] [Shi, Feng]Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Dept Biomed Sci, Los Angeles, CA 90048 USA
  • [ 7 ] [Wang, Qun]Tiantan Hosp, Dept Internal Neurol, Beijing, Peoples R China
  • [ 8 ] [Lu, Wangsheng]Puhua Int Hosp, Dept Internal Neurol, Beijing, Peoples R China
  • [ 9 ] [Li, Shaowu]Neurosurg Inst, Dept Funct Neuroimaging, Beijing, Peoples R China

通讯作者信息:

  • [Yang, Chunlan]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China

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来源 :

BRAIN TOPOGRAPHY

ISSN: 0896-0267

年份: 2018

期: 4

卷: 31

页码: 577-590

2 . 7 0 0

JCR@2022

ESI学科: NEUROSCIENCE & BEHAVIOR;

ESI高被引阀值:189

被引次数:

WoS核心集被引频次: 4

SCOPUS被引频次: 4

ESI高被引论文在榜: 0 展开所有

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