Polydopamine　(PDA)　simulates　the　adhesive　properties　of　mussels　and　modifies　the　surface　of　hydrophobic　materials.　In　this　study,　the　mussel-inspired　deposition　of　PDA　on　a　polyvinylidene　fluoride　support　was　adopted.　Afterward,　the　catecholamine　in　PDA　was　cross-linked　with　trimesoyl　chloride　(TMC).　Attenuated　total　reflectance-Fourier　transform　infrared　spectroscopy　and　x-ray　photoelectron　spectroscopy　validated　the　success　of　the　cross-linking　process.　Scanning　electron　microscopy　illustrated　that　the　cross-linking　induced　the　reduction　of　nodules.　Water　contact　angle　measurements　indicated　that　the　cross-linked　membrane　exhibited　a　higher　contact　angle　compared　with　the　pristine　membrane.　Atomic　force　microscopy　showed　that　the　cross-linked　membrane　surface　was　smoother　than　that　of　the　membrane　without　cross-linking.　Pervaporation　tests　demonstrated　that　the　cross-linked　membrane　could　separate　water　from　isopropanol.　Several　parameters　were　varied:　dopamine　concentration,　buffer　solution　pH,　self-polymerization　time,　TMC　concentration,　cross-linking　time,　and　annealing　time.　At　optimum　conditions,　the　permeate　flux　was　2411　+/-　33　g.m(-2).h(-1)　and　the　water　concentration　in　permeate　was　95.72　+/-　0.44　wt%　(feed　=　70　wt%　isopropanol　at　25　degrees　C).　At　a　feed　temperature　of　70　degrees　C,　the　permeate　flux　was　11001　+/-　989　g.m(-2).h(-1)　and　the　water　concentration　in　permeate　was　93.61　+/-　0.45　wt%.　This　indicates　that　a　composite　membrane　containing　cross-linked　PDA　is　stable　at　a　high　feed　temperature.