Quantitative explanation on structure-carcinogenic activity relationship of aromatic amines by di-region theory - 文章详情页

作者：

Dai, Q.-h. (Dai, Q.-h..) | Zheng, Q.-y. (Zheng, Q.-y..) | Wang, Z.-y. (Wang, Z.-y..) (学者：王智勇)

收录：

Scopus

摘要：

Di-region　theory,　the　theory　for　the　mechanism　of　carcinogenesis,　has　been　extended　successfully　on　the　quantitative　structure-carcinogenic　activity　relationship　(QSCAR)　of　63　aromatic　amines.　A　quantitative　equation　for　the　QSCAR　of　aromatic　amines　has　been　established　by　the　mechanism　conception　of　the　specialized　di-functional　alkylation　between　the　nitrenium　ion　of　the　amino　group　and　the　epoxide　of　the　aromatic　ring.　The　agreement　between　calculation　and　experiment　comes　up　to　98%.　Thus,　it　can　now　express　the　puzzling　variation　of　the　carcinogenicity　of　aromatic　amines,　as　a　comprehensible　structure-chemical　reactivity　relationship.　©　1991.

关键词：

aromatic amine; carcinogenesis turned on by transcription genes; di-region theory; mechanism of carcinogenesis; structure-carcinogenic activity relationship (SCAR)

作者机构：

[ 1 ] [Dai, Q.-h.]Center for Chemistry and Bioengineering of Cancer, Beijing Polytechnic University, Beijing, 100022, China
[ 2 ] [Zheng, Q.-y.]Center for Chemistry and Bioengineering of Cancer, Beijing Polytechnic University, Beijing, 100022, China
[ 3 ] [Wang, Z.-y.]Center for Chemistry and Bioengineering of Cancer, Beijing Polytechnic University, Beijing, 100022, China

通讯作者信息：

[Dai, Q.-h.]Center for Chemistry and Bioengineering of Cancer, Beijing Polytechnic University, Beijing, 100022, China

电子邮件地址：

查看成果更多字段

成果类型
所属机构

所有年份指定年份从至