Epoxy　group-functionalized　periodic　mesoporous　organosilicas　(FPMOs)　was　synthesized　by　the　co-condensation　of　1,2-bis　(triethoxysilyl)　ethane　(BTESE)　and　3-glycidoxypropyltrimethoxylsilane　(GPTMS)　in　the　presence　of　triblock　copolymer　poly　(ethylene　glycol)-b-poly　(propylene　glycol)-b-poly　(ethylene　glycol)　(P123)　under　acidic　conditions　and　utilized　as　a　support　for　laccase　immobilization.　The　effect　of　epoxy　group-functionalization　on　the　immobilization　of　laccase　and　the　stability　of　immobilized　laccase　were　investigated　in　detail.　The　level　of　functionalization,　the　pore　structure　and　the　laccase　immobilization　were　detected　by　means　of　solid-state　NMR,　N2　adsorption　and　UV-Vis,　respectively.　It　is　revealed　that　epoxy　groups　are　successfully　attached　covalently　to　the　pore　wall　of　PMOs　and　the　functionalized　materials　retain　a　desirable　pore　structure.　Laccase　immobilized　on　functionalized　FPMOs　exhibits　a　higher　activity　and　stability　than　that　adsorbed　on　pure　PMOs.