Three-dimensionally　ordered　macroporous　(3DOM)　LaMnAl11O19　and　xAuPd(y)/3DOM　LaMnAl11O19　(x　=　0.44　-　1.91　wt%;　y　=　1.80　-　1.86)　were　prepared　via　the　polymethyl　methacrylate　(PMMA)-templating　and　gas　bubble-assisted　polyvinyl　alcohol　(PVA)-protected　reduction　routes,　respectively.　Physicochemical　properties　of　the　samples　were　characterized　by　a　number　of　analytical　techniques.　Catalytic　activities　of　the　samples　were　measured　for　methane　combustion　in　a　continuous-flow　microreactor.　It　is　shown　that　the　LaMnAl11O19　in　each　of　the　samples　was　hexagonal　in　crystal　structure,　and　all　of　the　samples　possessed　a　good-quality　3DOM　architecture　with　a　surface　area　of　24.4　-　28.2　m(2)/g.　The　Au-Pd　nanoparticles　(NPs)　with　an　average　size　of　2.8　nm　were　uniformly　dispersed　on　the　macropore　walls　of　3DOM　LaMnAl11O19.　The　1.91AuPd(1.80)/3DOM　LaMnAl11O19　sample　performed　the　best　for　methane　combustion　(T-50%　=　342　degrees　C　and　T-90%　=　402　degrees　C　at　a　space　velocity　of　20,000　mL/(g　h)).　The　deactivation　of　the　1.91AuPd(1.80)/3DOM　LaMnAl11O19　catalyst　induced　by　water　vapor　introduction　was　reversible,　whereas　that　induced　by　SO2　addition　was　irreversible.　It　is　concluded　that　the　good　catalytic　activity　of　1.91AuPd(1.80)/3DOM　LaMnAl11O19　was　related　to　its　good-quality　3DOM　structure,　highly　dispersed　Au-Pd　NPs,　high　adsorbed　oxygen　species　concentration,　good　low-temperature　reducibility,　and　strong　interaction　between　Au-Pd　alloy　NPs　and　3DOM　LaMnAl11O19.