This　paper　presents　the　first　attempt　to　investigate　the　emission　source　control　of　the　Middle　Reaches　of　Yangtze　River　Urban　Agglomerations　(MRYRUA),　one　of　the　national　urban　agglomerations　in　China.　An　emission　inventory　of　the　MRYRUA　was　developed　as　inputs　to　the　CAMx　model　based　on　county-level　activity　data　obtained　by　full-coverage　investigation　and　source-based　spatial　surrogates.　A　classification　technology　method　for　priority　control　of　atmospheric　emission　sources　was　introduced　and　applied　in　the　MRYRUA　for　the　evaluation　of　the　emission　sources　control　on　the　region-scale　and　city-scale,　respectively.　The　results　demonstrated　that　the　emission　sources　in　the　Hefei-centered　urban　agglomerations　contributed　the　biggest　on　the　mean　PM2.5　concentrations　of　the　MRYRUA　and　should　be　taken　the　priority　to　control.　The　emission　sources　in　the　Ma＇anshan　city,　Xiangtan　city,　Hefei　city　and　Wuhan　city　were　the　bigger　contributors　on　the　mean　PM2.5　concentrations　of　the　MRYRUA　among　the　cities　and　should　be　taken　the　priority　to　control.　In　generally,　emission　sources　in　cities　along　the　Yangtze　River　and　the　tributary　should　be　given　the　special　attention　for　the　regional　air　quality　target　attainments.　This　study　can　give　an　understanding　of　Chinesee　missions　and　provide　a　valuable　preference　to　policy　makers　for　finding　effective　mitigation　measures　and　control　strategies　for　reducing　national　and　regional　air　pollution　in　China.　(c)　2017　Elsevier　B.V.　All　rights　reserved.