The　synthesis　of　hierarchical　lamellar　zeolites　with　a　controlled　meso-/microporous　morphology　and　acidity　is　an　expanding　area　of　research　interest　for　a　wide　range　of　applications.　Here,　we　report　a　onestep　synthesis　of　a　hierarchical　meso-/microporous　lamellar　MFI-Sn/Al　zeolite　(i.e.,　containing　both　Lewis　acidic　Sn-　and　Al-sites　and　a　Bronsted　acidic　Al-O(H)-Si　site)　and　its　catalytic　application　for　the　conversion　of　glucose　into　5-(ethoxymethyl)　furfural　(EMF).　The　MFI-Sn/Al　zeolite　was　prepared　with　the　assistance　of　a　diquaternary　ammonium　([C22H45-N+(CH3)(2)-C6H12-N+(CH3)(2)-C6H13]Br2-,　C22-6-6)　template　in　a　composition　of　100SiO(2)/5C(22-6-6)/18.5Na(2)O/xAl(2)O(3)/ySnO(2)/2957H(2)O　(x　=　0.5,　1,　and　2;　y　=　1　and　2,　respectively).　The　MFI-Sn/Al　zeolites　innovatively　feature　dual　meso-/microporosity　and　dual　Lewis　and　Bronsted　acidity,　which　enabled　a　three-step　reaction　cascade　for　EMF　synthesis　from　glucose　in　ethanol　solvent.　The　reaction　proceeded　via　the　isomerization　of　glucose　to　fructose　over　Lewis　acidic　Sn　sites　and　the　dehydration　of　fructose　to　5-hydroxymethylfurfural　(HMF)　and　then　the　etherification　of　HMF　and　ethanol　to　EMF　over　the　Bronsted　acidic　Al-O(H)-Si　sites.　The　co-existence　of　multiple　acidities　in　a　single　zeolite　catalyst　enabled　one-pot　cascade　reactions　for　carbohydrate　upgrading.　The　dual　meso-/microporosity　in　the　MFI-Sn/Al　zeolites　facilitated　mass　transport　in　processing　of　bulky　biomass　molecules.　The　balance　of　both　types　of　acidity　and　meso-/microporosity　realized　an　EMF　yield　as　high　as　44%　from　the　glucose　reactant.