Fe　pillared　sepiolite　(Fe-PILSEP)　was　prepared　by　the　intercalation　of　polymerization　of　iron　hydroxyl　ions　with　sepiolite　and　then　calcining　at　450　°C.　Cu　supported　on　Fe-PILSEP　catalysts　(xCu/Fe-PILSEP　(x　=5,　10,　15,　20wt%))　with　different　copper　loadings　were　prepared　by　impregnation　method.　xCu/Fe-PILSEP　were　characterized　by　X-ray　diffraction　(XRD),　X-ray　fluorescence　spectrometry　(XRF),　N　2-sorption　analysis,　H　2-Temperature-programmed　reduction　(TPR),　X-ray　photoelectron　spectroscopy　(XPS)　techniques　and　their　catalytic　performance　for　the　selective　catalytic　reduction　(SCR)　of　NO　by　propene　were　also　studied.　The　results　of　N　2-desorption/adsorption　and　TGA　show　that　due　to　pillaring,　there　is　a　distinctively　increase　of　Fe-PILSEP　in　surface　area,　pore　volume　and　thermal　stability.　XRD　and　XPS　results　verify　that　Fe　27Fe　3+　and　Cu7Cu　2+　are　co-existed,　respectively,　over　xCu/Fe-PILSEP　catalyst　and　there　is　some　strong　interaction　among　Cu,　Fe　and　sepiolite　support.　H2-TPR　results　show　that　there　are　isolated　Cu　2+　and　oxygenated　clusters　CuO　species　and　the　amount　of　latter　increases　with　copper　loading.　The　xCu/Fe-PILSEP　samples　display　significant　activity　in　the　NO　reduction　with　a　maximum　for　a　Cu　content　close　to　10wt%.　A　decay　of　catalytic　activity　is　observed　with　the　increase　of　copper　loading,　due　to　the　increase　of　oxygenated　clusters　CuO　species.