An　approach　using　direct　regularization　from　co-registered　dynamic　contrast　enhanced　magnetic　resonance　images　was　used　to　reconstruct　near-infrared　spectral　tomography　patient　images,　which　does　not　need　image　segmentation.　20　patients　with　mammography/ultrasound　confirmed　breast　abnormalities　were　involved　in　this　paper,　and　the　resulting　images　indicated　that　tumor　total　hemoglobin　concentration　contrast　differentiated　malignant　from　benign　cases　(p-value　=　0.021).　The　approach　produced　reconstructed　images,　which　significantly　reduced　surface　artifacts　near　the　source-detector　locations　(p-value　=　4.16e-6).