Design and synthesis of 2-styrylquinoline-7-sulfonamide derivatives as potential HIV iǹtegrase inhibitors - 文章详情页

作者：

Chengchu, Z. (Chengchu, Z..) | Liting, N. (Liting, N..) | Dawei, P. (Dawei, P..) | Rugang, Z. (Rugang, Z..)

收录：

Scopus PKU CSCD

摘要：

Accoring　to　the　steric,　electrostatic　and　H-bonding　features　of　the　CoMFA　model　which　was　stemmed　from　the　investigation　of　38　2-styrylquinoline　derivatives,　a　series　of　2-styrylquinoline-7-sulfonamide　derivatives　were　synthesized　and　evaluated　as　potential　HIV　integrase　inhibitors.　The　structures　of　all　compounds　were　characterized　by　NMR,　IR,　ESI-MS　and　HRMS　techniques.

关键词：

2-styrylquinoline-7-sulfonamide; Hiv ntegrase inhibitor; Perkin reaction

作者机构：

[ 1 ] [Chengchu, Z.]Collge of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
[ 2 ] [Liting, N.]Collge of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
[ 3 ] [Dawei, P.]Collge of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
[ 4 ] [Rugang, Z.]Collge of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China

通讯作者信息：

[Chengchu, Z.]Collge of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China

电子邮件地址：

zengcc@bjut.edu.cn

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