In　this　work,　the　fouling　resistance　of　0.1　mu　m　PVDF　microfiltration　membrane　fouled　with　humic　acid　(HA)　solution　during　NaCl　cleaning　process　was　systematically　studied.　Based　on　mass　balance　between　foulant　dissolution　and　foulant　re-deposition　on　the　membrane　surface　or　in　membrane　pores,　a　new　general　expression　of　cascade　kinetic　models　was　established　for　the　first　time　to　predict　the　variation　of　instantaneous　fouling　resistance　during　NaCl　cleaning.　The　results　showed　that　M1+1　model　was　the　optimal　kinetic　model　to　predict　the　instantaneous　fouling　resistance　of　0.1　mu　m　PVDF　membrane　in　NaCl　cleaning　process　by　comparing　the　experimental　data　with　model　predictions.　Meanwhile,　high　flux　recovery　of　94.20%　could　be　obtained　at　NaCl　concentration　of　100　mM　with　agitation　speed　of　600　rpm　and　temperature　of　35　degrees　C.　In　addition,　the　accuracy　of　M1+1　model　was　approved　by　a　series　of　long-term　experiments　with　several　cleaning　cycles,　the　other　membrane　and　cleaning　agent.　(C)　2018　Institution　of　Chemical　Engineers.　Published　by　Elsevier　B.V.　All　rights　reserved.