In　China,　chemical　enterprises　are　required　to　cluster　into　a　large　number　of　chemical　industrial　parks　(CIPs),　which　increase　risks　and　threats　to　the　environment　and　human　being＇s　health　due　to　aggregation　of　the　complicated　chemical　process　and　huge　unit　scale.　Setting　a　scientific　and　reasonable　protection　zone　around　CIP　is　a　very　efficient　way　to　protect　surrounding　people＇s　health.　A　method　was　designed　to　determine　the　comprehensive　protection　zone　of　CIP,　taking　into　account　multiple　factors:　air　quality,　health　risk　and　environmental　risk.　By　establishing　a　comprehensive　and　multi-levels　index　system,　the　protection　zone　and　the　corresponding　environmental　risk　management　countermeasures　can　be　proposed　hierarchically,　which　are　very　important　to　the　development　and　environmental　risk　management　of　CIP.　A　CIP　located　in　coastal　area　of　Shandong　Province　was　studied,　and　it　is　turned　out　that　the　method　to　determine　the　protection　zone　of　chemical　industrial　park　considering　air　quality,　health　risk　and　environmental　risk　has　great　advantages　compared　with　other　methods.