The　axial-torsional　thermo-mechanical　fatigue　behavior　for　Ni-based　superalloy　GH4169　was　investigated　experimentally　in　the　temperature　interval　from　360　degrees　C　to　650　degrees　C.　The　experimental　results　showed　that,　in　the　same　von　Mises　equivalent　mechanical　strain　amplitude　condition,　the　fatigue　life　can　be　seriously　decreased　when　the　axial　mechanical　strain　and　the　temperature　are　in-phase,　and　the　non-proportional　loading　of　mechanical　strains　can　result　in　the　fatigue　life　to　further　decrease.　The　analysis　results　showed　that　the　fatigue　lives　depend　on　the　summation　of　fatigue,　creep　and　oxidation　damages.　The　interaction　between　dislocations　and　precipitations　can　induce　the　additional　hardening　under　mechanical　non-proportional　loading,　which　can　obviously　increase　the　fatigue　damage.　The　tensile　mean　stress　and　the　non-proportional　additional　hardening　can　further　increase　the　oxidation　damage　existed　in　all　loading　conditions,　which　result　in　the　increase　of　inelastic　strain　at　high　temperature.　Creep　damage　behavior　on　grain　boundaries　can　be　shown　in　the　case　of　the　high　tensile　stress　and　the　high　temperature　acting　simultaneously,　and　increased　with　shear　stress　at　the　same　time.　In　addition,　the　tensile　stress　has　an　obvious　effect　on　the　nucleation　of　creep　cavities　contrasted　to　the　shear　stress　at　high　temperature,　and　more　creep　damage　can　be　caused　by　the　non-proportional　additional　hardening.