The　layered　transition　metal　dichalcogenides,　molybdenum　disulfide　(MoS2)　have　received　increasing　attention　and　hold　great　potential　applications　in　various　fields　due　to　its　unique　properties.　In　this　work,　the　PDDA　modified　MoS2　nanosheets　(PDDA@MoS2　nanosheets)　were　prepared　and　then　incorporated　into　polyelectrolyte　multilayers　through　layer-by-layer　self-assembly　method　to　get　a　PDDA@MoS2-PDDA/PSS　hybrid　membrane.　The　morphologies　and　structures　of　the　resulted　PDDA@MoS2　nanosheets　and　hybrid　membranes　were　characterized　by　X-ray　diffraction,　scanning　electron　microscope,　transmission　electron　microscopy,　X-ray　photoelectron　spectroscopy,　energy　dispersive　spectroscopy　and　atom　force　microscopy.　The　nanofiltration　performance　of　the　hybrid　membranes　were　investigated　by　retention　of　dyes　and　salts　from　aqueous　solution.　The　result　indicated　that　the　hybrid　membranes　showed　98.4%　retention　of　methyl　blue　with　flux　of　194.4　L/m(2)　h　MPa,　which　was　2.3　times　than　that　of　pure　poly　electrolytes　membrane　with　flux　of　82.7　L/m(2)　h　MPa.　And　the　hybrid　membrane　also　showed　rejection　of　salts　in　the　sequence　Na2SO4　＞　MgSO4　＞　NaCl　＞　MgCl2.　Moreover,　the　flux　of　the　membrane　remained　around　180.0　L/m(2)　h　MPa,　while　the　rejection　was　maintained　at　about　98.0%　during　the　165　h　running　time,　displaying　good　long　term　stability.　(C)　2018　Taiwan　Institute　of　Chemical　Engineers.　Published　by　Elsevier　B.V.　All　rights　reserved.