Spherical　lattice　shell　is　a　typical　long-span　space　structure　and　its　seismic　response　is　evidently　influenced　by　horizontal　and　vertical　components　of　ground　motion.　Bearing-type　isolation　devices　can　be　utilized　to　form　a　segmented　multidimensional　isolation　mechanism　to　improve　the　seismic　performance　of　the　spherical　lattice　shell　structures.　In　such　structures,　disc　spring　bearings　can　be　introduced　to　constitute　a　vertical　isolation　system　and　cooperate　with　two　types　of　horizontal　isolation　device;　(1)the　friction　pendulum　system　(FPS)　bearings;　(2)the　SMA　-　rubber　bearings.　Based　on　conceptual　design　mentioned　above,　the　configuration　plans　of　the　vertical　and　horizontal　isolation　bearing　were　developed,　and　the　corresponding　calculation　models　were　established.　According　to　dynamic　equations　for　the　lattice　shell　structures　with　multidimensional　seismic　isolation　system,　seismic　analysis　was　executed　for　both　double-layer　and　single-layer　spherical　lattice　shell　under　El　Centro　wave.　The　numerical　simulation　results　show　that　the　vibration-reduction　effectiveness　of　the　internal　force,　acceleration　and　displacement　of　such　seismically　isolated　structures　is　up　to　50%　or　more.　Therefore,　the　presented　multidimensional　isolation　technology　can　be　effectively　used　to　protect　the　spherical　lattice　shell　structures　from　damages　of　earthquake.