This　paper　presented　an　integrated　computational-experimental　approach　for　evaluating　elastic　modulus　of　cement　paste　corroded　in　brine　solution　on　nanoscale.　In　the　first　place,　the　cured　specimens　were　corroded　in　brine　solution　at　room　temperature　for　90　days.　Subsequently,　the　elastic　moduli　of　32　points　of　the　corroded　cement　paste　specimen　were　measured　by　nanoindentation　test.　Then,　a　three-dimensional　nanoindentation　model　was　established　with　finite　element　method　and　modified　constitutive　relation.　The　input　parameters　of　the　model　were　calibrated　based　on　the　test　results　and　linear　interpolation　method.　Finally,　the　difference　between　the　simulation　results　and　the　experimental　results　was　compared　with　good　agreement.　Therefore,　the　nanoindentation　model　established　in　this　paper　can　predict　the　nanoindentation　experiment　well　and　the　modified　constitutive　relation　is　effective.　(C)　2017　Elsevier　Ltd.　All　rights　reserved.