This　paper　studied　the　spot　welding　structure　of　ultra-high　strength　steel　22MnB5.　ANSYS　software　was　adopted　to　simulate　its　static　strength;　BS5400　algorithm　was　used　to　calculate　the　fatigue　life;　and　the　grouping　method　was　used　to　test　the　fatigue　performance　of　tensile　shear　spot　weld　specimens.　The　simulation　results　were　in　good　agreement　with　the　experimental　values.　Based　on　the　validation　of　the　simulation　method,　influences　of　different　structural　parameters　on　static　strength　and　fatigue　life　were　explored　by　adopting　single　factor.　The　results　showed　that　within　the　selected　structure　parameter　range,　increase　of　the　sheet　thickness,　nugget　diameter,　sheet　width　and　overlapping　length　can　lead　to　longer　fatigue　life.　Besides,　the　fatigue　life　of　spot　weld　took　on　a　linear　relationship　with　the　overlapping　length,　a　DoseResp　relationship　with　the　sheet　thickness,　and　a　single　exponential　decay　relationship　with　the　sheet　width　and　the　nugget　diameter.　Moreover,　in　order　to　estimate　the　impact　from　various　parameters　on　the　fatigue　life　of　the　specimens,　the　Taguchi　orthogonal　design　method　was　applied　in　the　simulation　design.　The　simulating　result　indicated　that　influence　of　the　sheet　thickness　on　fatigue　life　was　the　most　significant.　In　addition,　the　effects　of　nugget　diameter,　sheet　width　and　overlapping　length　on　fatigue　life　were　reduced　in　turn.　Copyright:　©　2016　Editorial　Board　of　CHINA　WELDING.