Controlled　wettability　of　liquids　on　bioceramic　surfaces　has　recently　received　widespread　attention.　Here,　tunable　wettability　of　yttria-stabilized　tetragonal　zirconia　polycrystals　(Y-TZP,　3　mol%　yttria)　bioceramic　surface　was　achieved　by　ultrafast　laser　micro-fabrication.　Two　surface　microstructures,　arc　grooves　and　square　pillar　arrays,　were　designed　based　on　the　Wenzel　and　Cassie　model,　and　then　fabricated　by　355　nm　picosecond　laser　with　high　controllability　and　quality.　The　contact　angle　of　the　treated　surface　was　tunable　from　superhydrophilicity　(10　degrees)　to　hydrophobicity　(133　degrees)　by　changing　the　microstructure　characteristics　with　laser　processing.　The　microstructures　with　uniform　size,　crack-free,　smooth　edges　and　alleviated　taper　were　achieved.　In　addition,　the　laser-treated　Y-TZP　ceramic　surfaces　were　biocompatible　for　cell　adhesion　and　growth.　The　range　of　the　optimized　parameters　was　also　determined　based　on　the　study　of　the　interaction　of　the　laser　with　the　Y-TZP　ceramics.