Objective　To　design　and　synthesze　novel　pyrrolopyridine　as　integrase　inhibitors.　Method　The　launched　anti-HIV　drug　raltegravir　was　selected　as　template　compounds.　According　to　the　concept　of　bioisosterism　and　molecular　docking,　a　series　of　pyrrolopyridine　compounds　(6a-6t)　were　designed,　synthesized　and　their　anti-integrase　3’-processing　activity　were　analyzed.　Results　The　designed　compounds　were　successfully　synthesized　and　the　structures　of　these　compounds　were　confirmed　by　1H　NMR,　13C　NMR　and　ESI-HRMS.　The　anti-IN　3’-P　activity　of　these　compounds　were　also　measured.　The　binding　mode　and　docking　energy　of　representative　compounds　were　analyzed.　Conclusion　The　structure-activity　relationships　of　these　compounds　were　also　analyzed　by　the　results　of　docking.　These　results　lay　the　foundation　for　the　further　optimization　of　these　compounds.　©　2016,　Editorial　office　of　Journal　of　International　Pharmaceutical　Research.　All　rights　reserved.