To　study　the　effect　of　microchannel　inlet　angle　on　the　droplet　generation　process　under　the　condition　of　varying　fluid　physical　parameters,　a　three　dimensional　numerical　simulation　in　the　cross-flow　microchannel　was　proposed　by　the　volume　of　fluid　(VOF)　method.　The　two-phase　pressure　difference　in　the　droplet　generation　process,　the　time　period　and　size　of　the　microdroplet　were　studied.　The　results　show　that　the　microdroplet　size　decreases　firstly　and　then　increases　gradually　with　the　increase　of　the　inlet　angle　in　the　squeezing　regime.　A　90°　inlet　angle　is　helpful　to　generating　shortest　droplet　for　high　surface　tension　or　low　viscosity　of　continuous　phase;　A　120°　inlet　angle　is　conducive　to　generating　shortest　droplet　for　low　surface　tension　or　high　viscosity　of　continuous　phase.　For　constant　inlet　angle,　the　microdroplet　size　rises　with　the　increase　of　the　surface　tension　coefficient　and　reduces　with　the　increase　of　the　viscosity　of　continuous　phase.　The　shortest　droplet　is　generated　in　different　microchannel　for　varying　fluid　physical　parameters.　Considering　the　inlet　angle,　surface　tension　coefficient　and　viscosity　of　continuous　phase,　the　new　correlation　of　the　dimensionless　droplet　length　for　the　squeezing　regime　is　proposed　which　can　provide　guidance　for　the　design　and　application　of　the　microdroplet　system.　©　2016,　Editorial　Department　of　Journal　of　Beijing　University　of　Technology.　All　right　reserved.